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Table 2 Characteristics of industry-sponsored clinical trials performed exclusively within one major geographic group a

From: Industry-sponsored clinical research outside high-income countries: an empirical analysis of registered clinical trials from 2006 to 2013

Study characteristic

Major geographic group

Americas N = 406

Middle East/Africa N = 163

Asia N = 1138

Europe (non-Western) N = 256

High-income regions N = 16,246

Median study sites, N (IQR)

1 c

1 c

1 c

2 c

1

(1–2)

(1–3)

(1–4)

(1–9)

(1–9)

Median subjects enrolled, N (IQR)

100 c

183 c

142 c

120 c

71

(48–200)

(90–400)

(50–300)

(47–259)

(33–188)

Double-blinded, N (%)

191 c

73 c

502 c

168

9938

(46.9)

(44.7)

(44.1)

(65.6)

(61.1)

Industry as lead funder, N (%)

345 c

115 c

998 c

236 c

13 133

(84.8)

(70.5)

(87.7)

(92.2)

(80.8)

Phase 3 or 4, N (%)

250 c

73 c

589 c

104 c

5345

(61.6)

(44.7)

(51.7)

(40.6)

(32.9)

Paediatric b N (%)

42 c

51 c

120 c

28 c

699

(10.3)

(31.3)

(10.5)

(10.9)

(4.2)

  1. a 18,209 (80.9 %) of all trials were conducted exclusively in one region and are included in the table
  2. b Defined as listed maximum age <19, or if listed maximum age above 19, median age <19. If no maximum age listed, trial assumed to be adult
  3. cP <0.05 by χ2 or Mann–Whitney testing when compared with high-income regions