From: Does a biomedical research centre affect patient care in local hospitals?
BRC Research theme/Working group | Oxford BRC projects with potential impact on patient care | Potential impact on patient care at OUH | OUH senior clinician mentioned impact unprompted?a | OUH senior clinician confirmed impact after prompting?a |
---|---|---|---|---|
Biomedical Informatics and Technology | Gestational diabetes smartphone application | Processes and/or service organisation | YES | n.a. |
New alerting score based on patients’ vital signs (CALMS-3 Study – Computer Alerting Monitoring System) | Processes and/or service organisation | NO | NO | |
Maintenance of database of samples and consent management for Oxford Biobank | Processes and/or service organisation | NO | YES | |
System for Electronic Notes Documentation (SEND) project (electronic track and trigger and patient alerting) | Processes and/or service organisation | YES | n.a. | |
Blood | Training and hiring staff and improving infrastructure for clinical programme to do stem cell transplants and run more clinical trials in this area | Treatments | NO | NO |
Cancer | Multi-gene testing service with rapid (1 week) turnaround | Diagnostics, testing, screening | NO | YES |
BRC-funded clinical research posts specialising in sarcoma, gynaecological cancers and melanoma | Staffing for specialist services | NO | NO | |
Cardiovascular | MRI diagnostic tools for patients with intermittent angina | Diagnostics, testing, screening | NO | YES |
Clinical Informatics | Upgrade for cancer informatics in OUH (enabled by Genomic Medicine Centre (GMC) designation) | Diagnostics, testing, screening | NO | NO |
Molecular diagnostics and genome sequencing services (enabled by GMC designation) | Diagnostics, testing, screening | NO | NO | |
Development of integrated logical record for each cancer patient (in progress) | Processes and/or service organisation | NO | YES | |
True colours technology for mental health patients across Oxfordshire to aid self-management | Processes and/or service organisation | NO | YES | |
Streamlining management of notes/records from multidisciplinary cancer meetings (in progress) | Processes and/or service organisation | NO | YES | |
Clinical decision support dialogue to make blood orders more efficient | Processes and/or service organisation | NO | NO | |
Dementia and Cerebrovascular Disease | New screening process for acute confusion in medical admissions | Diagnostics, testing, screening | NO | YES |
Fast track carotid surgery | Treatments | NO | NO | |
Telemetric home blood pressure monitoring | Processes and/or service organisation | NO | NO | |
The first transient ischaemic attack (TIA) and minor stroke clinic in the United Kingdom | Processes and/or service organisation | YES | n.a. | |
Diabetes | Diagnostic programme to identify patients with a genetic basis for their diabetes | Diagnostics, testing, screening | NO | NO |
Pancreatic islet extraction unit | Treatments | NO | NO | |
Pancreatic transplants | Treatments | NO | NO | |
Functional Neuroscience and Imaging | Imaging protocols (epilepsy) | Diagnostics, testing, screening | NO | NO |
Functional neurosurgery team (part of the BRC) provides a clinical service, including pain deep brain stimulation | Treatments | NO | NO | |
Specialist clinic in epilepsy, Parkinson’s disease, motor neurone disease, supported by BRC-funded research fellows | Staffing for specialist services | NO | NO | |
Genomic Medicine | Targeted next generation sequencing | Diagnostics, testing, screening | NO | NO |
Whole exome or whole genome sequencing | Diagnostics, testing, screening | NO | NO | |
Immunology and Inflammation | Non-invasive tests for liver disease | Diagnostics, testing, screening | YES | n.a. |
Patient stratification for biologic therapies | Diagnostics, testing, screening | NO | YES | |
Tests to diagnose encephalitis (brain inflammation) | Diagnostics, testing, screening | NO | NO | |
Trials on treatment of inflammation in eczema | Treatments | NO | NO | |
Infection | Work linking care to outcomes with big data approaches | Processes and/or service organisation | NO | NO |
Genomic testing to support infection monitoring (provided informally) | Processes and/or service organisation | NO | NO | |
Molecular Diagnostics | Oxford designated as GMC for Genomics England’s 100,000 Genomes Project | Diagnostics, testing, screening | YES | n.a. |
Multi-gene testing for cancer patients | Diagnostics, testing, screening | NO | YES | |
Diagnostic tests for children with rare blood conditions | Diagnostics, testing, screening | NO | NO | |
Response prediction in leukaemia | Diagnostics, testing, screening | NO | YES | |
Prevention and Population Care | The first TIA and minor stroke clinic in the United Kingdom | Processes and/or service organisation | YES | n.a. |
Surgical Innovation and Evaluation | Chemotherapy (device targeted therapy): liposomes developed to carry the treatment to the organ of interest | Treatments | NO | NO |
Image-guided surgery using fluorescents | Treatments | YES | n.a. | |
Organ transplantation/reconditioning | Treatments | NO | NO | |
Restoring vision through an electronic implant | Treatments | YES | n.a. | |
Restoring vision through gene therapy | Treatments | YES | n.a. | |
Training and Education | No projects identified | |||
Translational Physiology | No projects identified | Diagnostics, testing, screening | YES | n.a. |
Vaccines | Respiratory syncytial virus, trialling a new vaccineb | Treatments (national) | YES | n.a. |
Meningitis, looking at trials of schedules for baby vaccines, booster doses, meningitis B vaccine trialsb | Processes and/or service organisation (national) | YES | n.a. | |
Multiple Research themes/Working groups | Better infrastructure for clinical trials and other studies (e.g. better pharmacovigilance, biobanking) | Processes and/or service organisation | NO | YES |