Skip to main content

Table 4 Median days to alleviation in high-risk subgroups

From: Why European and United States drug regulators are not speaking with one voice on anti-influenza drugs: regulatory review methodologies and the importance of ‘deep’ product reviews

Trial

Southern Hemisphere (NAIB3001)

Europe (NAIB3002)

North America (NAIA3002)

Elderly

n = 9

n = 12

n = 37

Placebo

13

> 26.5

7.25

Relenza

2.75

11

4.5

Differencea

10.25

> 15.5

2.75

Cardiovascular

n = 3

n = 6

n = 19

Placebo

8.5

16.5

7

Relenza

1.5

21

7.5

Differencea

7.0

–4.5

–0.5

Respiratory

n = 41

n = 17

n = 36

Placebo

7

10.75

5.5

Relenza

5.5

6.5

8.75

Differencea

1.5

4.25

–3.25

Endocrine/metabolic

n = 6

N/A

N/A

Placebo

13

  

Relenza

4

  

Differencea

9

  

Immune compromised

n=2

N/A

N/A

Placebo

4.5

  

Relenza

3

  

Differencea

1.5

  
  1. a Differences are statistically non-significant