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Table 3 Clinical outcomes at 90 days in patients by type of stroke research centre

From: The National Institute for Health Research Hyperacute Stroke Research Centres and the ENCHANTED trial: the impact of enhanced research infrastructure on trial metrics and patient outcomes

  n (%) Unadjusted OR (95% CI) p value Adjusted ORa (95% CI) p value Adjusted ORb (95% CI) p trend
Death or disability (mRS 2 to 6)
 Non-HSRC 165/256 (64.5) 1.0 0.004 1.0 0.05 1.0 0.87
 HSRC 249/467 (53.3) 0.63 (0.46–0.86)   0.71 (0.50–1.01)   0.97 (0.64–1.46)
Death or disability (mRS 3 to 6)
 Non-HSRC 121/256 (47.3) 1.0 0.017 1.0 0.27 1.0 0.82
 HSRC 178/467 (38.1) 0.69 (0.50–0.82)   0.82 (0.57–1.17)   1.05 (0.68–1.62)
Death
 Non-HSRC 34/272 (12.5) 1.0 0.24 1.0 0.60 1.0 0.58
 HSRC 49/502 (9.8) 0.76 (0.48–1.21)   0.87 (0.51–1.47)   1.21 (0.61–2.39)
mRS categories
 Non-HSRC   1.0 0.005 1.0 0.15 1.0 0.77
  0 37 (14.5)    
  1 54 (21.1)    
  2 44 (17.2)    
  3 45 (17.6)    
  4 23 (9.0)    
  5 19 (7.4)    
  6 34 (13.3)    
 HSRC   0.68 (0.52–0.89) 0.82 (0.62–1.08) 1.05 (0.77–1.43)
  0 100 (21.4)    
  1 118 (25.3)    
  2 71 (15.2)    
  3 61 (13.1)    
  4 42 (9.0)    
  5 26 (5.6)    
  6 34 (13.3)    
  1. CI confidence interval, HSRC hyperacute stroke research centre, mRS modified Rankin score, OR odds ratio, aOR adjusted odds ratio
  2. aModel 1: adjusted analysis for minimisation variables including National Institutes of Health Stroke Scale score and time from stroke onset to randomisation, and baseline variables: age, sex, ethnicity, systolic blood pressure, heart rate, hypercholesterolaemia, current smoker, premorbid mRS, premorbid use of antihypertensive therapy, aspirin or other antiplatelet agent, and randomised treatment (low dose versus standard dose)
  3. bModel 2: as Model 1, plus systolic blood pressure at 24 h, fever occurrence, nasogastric feeding given, subcutaneous heparin used, patient mobilised by therapist, any stroke unit admission, any neurosurgery performed, and any rehabilitation given