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Table 1 Selected trial metrics and management of patients by type of stroke research centre

From: The National Institute for Health Research Hyperacute Stroke Research Centres and the ENCHANTED trial: the impact of enhanced research infrastructure on trial metrics and patient outcomes

  All United Kingdom (n = 774) HSRC (n = 502) Non-HSRC (n = 272) p value
Number of recruiting centres (n) 33 9 24  
Monthly recruitment rate (median, IQR) 1.0 (0.6–1.5) 1.5 (1.4–2.2) 0.7 (0.5–1.3) 0.01
Time from stroke onset to treatment, mins (median, IQR) 139 (110–175) 135.5 (110–178) 140.0 (111–174) 0.65
Time from randomisation to treatment, mins (median, IQR) 2.8 (0.2–5.4) 2.6 (−0.6 to 5.3) 3.1 (1.1–5.7) 0.01
Alteplase given (n/N, %) 765/774 (98.8) 498/502 (99.2) 267/272 (98.2) 0.20
Cerebral angiogram (n/N, %) 22/774 (2.8) 20/502 (4.0) 2/272 (0.7) 0.009
 Occluded vessel (n/N, %) 18/22 (81.8) 17/20 (85.0) 1/2 (50.0) 0.22
 Endovascular therapy (n/N, %) 16/22 (72.7) 15/20 (75.0) 1/2 (50.0) 0.45
  1. HSRC hyperacute stroke research centre, IQR interquartile range