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Table 2 Baseline characteristics of patients by type of stroke research centre

From: The National Institute for Health Research Hyperacute Stroke Research Centres and the ENCHANTED trial: the impact of enhanced research infrastructure on trial metrics and patient outcomes

  All United Kingdom (n = 774) HSRC (n = 502) Non-HSRC (n = 272) p value
Time from stroke onset to randomisation, hours (median, IQR) 2.3 (1.8–2.9) 2.2 (1.8–2.9) 2.3 (1.8–2.8) 0.82
Age, years (mean, SD) 72 (14) 71 (14) 75 (13) 0.0002
Female (n/N, %) 318/774 (41.1) 203/502 (40.4) 115/272 (42.3) 0.62
Non-Asian ethnicity (n/N, %) 757/774 (97.8) 490/502 (97.6) 267/272 (98.2) 0.62
Systolic BP, mmHg (mean, SD) 151 (20) 151 (19) 152 (20) 0.52
Heart rate, bpm (mean, SD) 80 (18) 82 (18) 77 (17) 0.0003
NIHSS score (median, IQR) 7 (5–13) 7 (5–11) 8 (5–14) 0.01
GCS score (median, IQR) 15 (14–15) 15 (14–15) 15 (14–15) 0.01
History of hypertension (n/N, %) 472/774 (61.0) 299/502 (59.6) 173/272 (63.6) 0.27
History of coronary artery disease (n/N, %) 112/774 (14.5) 73/502 (14.5) 39/272 (14.3) 0.94
AF confirmed on ECG (n/N, %) 188/772 (24.4) 117/500 (23.4) 71/272 (26.1) 0.40
Hypercholesterolaemia (n/N, %) 260/774 (33.6) 161/502 (32.1) 99/272 (36.4) 0.22
Current smoker (n/N, %) 124/770 (16.1) 92/501 (18.4) 32/269 (11.9) 0.02
Pre-stroke symptoms on the mRS (n/N, %) 240/773 (31.0) 149/501 (29.7) 91/272 (33.5) 0.29
Antihypertensive therapy (n/N, %) 429/774 (55.4) 264/502 (52.6) 165/272 (60.7) 0.03
Warfarin anticoagulation (n/N, %) 23/773 (3.0) 18/501 (3.6) 5/272 (1.8) 0.17
Aspirin/other antiplatelet (n/N, %) 273/773 (35.3) 178/501 (35.5) 95/272 (34.9) 0.87
Statin/other lipid lowering (n/N, %) 103/773 (13.3) 66/501 (13.2) 37/272 (13.6) 0.87
Brain imaging features
 CT scan used (n/N, %) 769/774 (99.4) 502/502 (100) 267/272 (98.2) 0.002
 MRI scan used (n/N, %) 8/774 (1.0) 4/502 (0.8) 4/272 (1.5) 0.38
 Visible early ischaemic changes (n/N, %) 230/774 (29.7) 156/502 (31.1) 74/272 (15.1) 0.26
 Visible cerebral infarction (n/N, %) 144/774 (18.6) 103/502 (20.5) 1/272 (0.4) 0.06
Final diagnosis
 Non-stroke (n/N, %) 50/768 (6.5) 33/498 (6.6) 17/270 (6.3) 0.86
 Large artery occlusion (n/N, %) 170/713 (23.8) 129/461 (28.0) 41/252 (16.3) 0.003
 Small vessel disease (n/N, %) 139/713 (19.5) 91/461 (19.7) 48/252 (19.0)  
 Cardioembolism (n/N, %) 181/713 (25.4) 106/461 (23.0) 75/252 (29.8)
 Other or uncertain aetiology (n/N, %) 223/713 (31.3) 135/461 (29.3) 88/252 (34.9)
  1. HSRC Hyperacute Stroke Research Centre, BP blood pressure, NIHSS National Institutes of Health Stroke Scale, GCS Glasgow coma scale, AF atrial fibrillation, mRS modified Rankin scale