Table 2 Baseline characteristics of patients by type of stroke research centre
All United Kingdom (n = 774) | HSRC (n = 502) | Non-HSRC (n = 272) | p value | |
|---|---|---|---|---|
Time from stroke onset to randomisation, hours (median, IQR) | 2.3 (1.8–2.9) | 2.2 (1.8–2.9) | 2.3 (1.8–2.8) | 0.82 |
Age, years (mean, SD) | 72 (14) | 71 (14) | 75 (13) | 0.0002 |
Female (n/N, %) | 318/774 (41.1) | 203/502 (40.4) | 115/272 (42.3) | 0.62 |
Non-Asian ethnicity (n/N, %) | 757/774 (97.8) | 490/502 (97.6) | 267/272 (98.2) | 0.62 |
Systolic BP, mmHg (mean, SD) | 151 (20) | 151 (19) | 152 (20) | 0.52 |
Heart rate, bpm (mean, SD) | 80 (18) | 82 (18) | 77 (17) | 0.0003 |
NIHSS score (median, IQR) | 7 (5–13) | 7 (5–11) | 8 (5–14) | 0.01 |
GCS score (median, IQR) | 15 (14–15) | 15 (14–15) | 15 (14–15) | 0.01 |
History of hypertension (n/N, %) | 472/774 (61.0) | 299/502 (59.6) | 173/272 (63.6) | 0.27 |
History of coronary artery disease (n/N, %) | 112/774 (14.5) | 73/502 (14.5) | 39/272 (14.3) | 0.94 |
AF confirmed on ECG (n/N, %) | 188/772 (24.4) | 117/500 (23.4) | 71/272 (26.1) | 0.40 |
Hypercholesterolaemia (n/N, %) | 260/774 (33.6) | 161/502 (32.1) | 99/272 (36.4) | 0.22 |
Current smoker (n/N, %) | 124/770 (16.1) | 92/501 (18.4) | 32/269 (11.9) | 0.02 |
Pre-stroke symptoms on the mRS (n/N, %) | 240/773 (31.0) | 149/501 (29.7) | 91/272 (33.5) | 0.29 |
Antihypertensive therapy (n/N, %) | 429/774 (55.4) | 264/502 (52.6) | 165/272 (60.7) | 0.03 |
Warfarin anticoagulation (n/N, %) | 23/773 (3.0) | 18/501 (3.6) | 5/272 (1.8) | 0.17 |
Aspirin/other antiplatelet (n/N, %) | 273/773 (35.3) | 178/501 (35.5) | 95/272 (34.9) | 0.87 |
Statin/other lipid lowering (n/N, %) | 103/773 (13.3) | 66/501 (13.2) | 37/272 (13.6) | 0.87 |
Brain imaging features | ||||
CT scan used (n/N, %) | 769/774 (99.4) | 502/502 (100) | 267/272 (98.2) | 0.002 |
MRI scan used (n/N, %) | 8/774 (1.0) | 4/502 (0.8) | 4/272 (1.5) | 0.38 |
Visible early ischaemic changes (n/N, %) | 230/774 (29.7) | 156/502 (31.1) | 74/272 (15.1) | 0.26 |
Visible cerebral infarction (n/N, %) | 144/774 (18.6) | 103/502 (20.5) | 1/272 (0.4) | 0.06 |
Final diagnosis | ||||
Non-stroke (n/N, %) | 50/768 (6.5) | 33/498 (6.6) | 17/270 (6.3) | 0.86 |
Large artery occlusion (n/N, %) | 170/713 (23.8) | 129/461 (28.0) | 41/252 (16.3) | 0.003 |
Small vessel disease (n/N, %) | 139/713 (19.5) | 91/461 (19.7) | 48/252 (19.0) | |
Cardioembolism (n/N, %) | 181/713 (25.4) | 106/461 (23.0) | 75/252 (29.8) | |
Other or uncertain aetiology (n/N, %) | 223/713 (31.3) | 135/461 (29.3) | 88/252 (34.9) | |