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Table 4 Level of evidence

From: Development and validation of a guideline on sexual and reproductive health of breast cancer survivors in Iran: a mixed methods study protocol

Level

Definition

1: Strong

Randomized clinical trials or their meta-analysis

2: Intermediate

Non-randomized clinical trials and their meta-analysis

Case–control studies or their meta analysis

Prospective cohort studies

3: Weak

Cross-sectional studies, observational studies, case series, or case reports

4: No evidence

Insufficient evidence

  1. Adapted [38] from American Association of Clinical Endocrinologists (AACE) protocol for standardized production of clinical practice guidelines [39]