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Table 1 LHS evidence quadrants mapped against the various phases of EBG development

From: Learning health systems and evidence ecosystems: a perspective on the future of evidence-based medicine and evidence-based guideline development

LHS evidence quadrant

EBG development phase

Example activity

Evidence from stakeholders

Phase 1: Establish GDG and scope

The development of the 2018 International PCOS Guidelines involved extensive engagement with 3500 stakeholders in partnerships, surveys and workshops to set priorities and rank outcomes of importance for guideline inclusion [25]

Evidence from research

Phase 2: Systematic review of evidence

Phase 3: Formulate guidance

The development of the 2018 International PCOS Guidelines featured the production of 19 systematic reviews for more than 65 clinical questions [25]

Evidence from data

Phase 4: Disseminate, implement, evaluate and update

Evaluation of the 2018 International PCOS Guideline implementation into practice has evaluated alignment of practice with recommendations, as well as alignment of patient and healthcare provider satisfaction with care, to inform ongoing improvement [23], thus informing model of care framework being scaled internationally

Evidence from implementation

Phase 4: Disseminate, implement, evaluate and update

In the 2018 International PCOS evidence-based guidelines, a free accessible patient app, ASKPCOS, was co-designed with patients and has been implemented with more than 37 000 women in 186 countries [24]