- Open Access
- Open Peer Review
This article has Open Peer Review reports available.
United Kingdom health research analyses and the benefits of shared data
© The Author(s). 2016
Received: 13 November 2015
Accepted: 1 June 2016
Published: 24 June 2016
To allow research organisations to co-ordinate activity to the benefit of national and international funding strategies requires assessment of the funding landscape; this, in turn, relies on a consistent approach for comparing expenditure on research. Here, we discuss the impact and benefits of the United Kingdom’s Health Research Classification System (HRCS) in national landscaping analysis of health research and the pros and cons of performing large-scale funding analyses.
The first United Kingdom health research analysis (2004/2005) brought together the 11 largest public and charity funders of health research to develop the HRCS and use this categorisation to examine United Kingdom health research. The analysis was revisited in 2009/2010 and again in 2014. The most recent quinquennial analysis in 2014 compiled data from 64 United Kingdom research organisations, accounting for 91% of all public/charitable health research funding in the United Kingdom. The three analyses summarise the United Kingdom’s health research expenditure in 2004/2005, 2009/2010 and 2014, and can be used to identify changes in research activity and disease focus over this 10 year period.
The 2004/2005 analysis provided a baseline for future reporting and evidence for a United Kingdom Government review that recommended the co-ordination of United Kingdom health research should be strengthened to accelerate the translation of basic research into clinical and economic benefits. Through the second and third analyses, we observed strategic prioritisation of certain health research activities and disease areas, with a strong trend toward increased funding for more translational research, and increases in specific areas such as research on prevention.
The use of HRCS in the United Kingdom to analyse the research landscape has provided benefit both to individual participatory funders and in coordinating initiatives at a national level. A modest amount of data for each project is sufficient for a nationwide assessment of health research funding, but achieving coverage of the United Kingdom portfolio relies on sourcing these details from a large number of individual funding agencies. The effort needed to compile this data could be minimised if funders routinely shared or published this information in a standard and accessible way. The United Kingdom approach to landscaping analyses could be readily adapted to suit other groups or nations, and global availability of research funding data would support better national and international coordination of health research.
Health research seeks to address some of the most economically significant challenges facing society. In the United Kingdom, the Department of Health (England) has estimated costs of more than £5 billion per year to the National Health Service (NHS)  and £27 billion to the economy  due to obesity, with almost 1 in 4 adults and around 15% of children being obese . In 2014, the United Kingdom Alzheimer’s Society published a major study on the social and economic impact of dementia in the United Kingdom, which estimated that there will be 850,000 people living with dementia in the United Kingdom by 2015 and that dementia already costs the country £26 billion a year .
Therefore, changes to health service delivery and healthcare, informed by health research, has the potential to bring substantial economic and wider societal impacts. In addition, publically-funded health research is an important attractor for investment from a global, research-intensive pharmaceutical industry which in turn can bring additional associated spill-over benefits . A recent analysis of the impact case studies submitted via the 2014 United Kingdom Research Excellence Framework exercise identified £2 billion of health gain from 11 such impacts alone in the period 2008–2012 . Investment in health research is therefore widely regarded as generating positive economic returns , but estimations of these returns are often highly caveated and, indeed, the means to measure such returns require further development .
One challenge to obtaining better estimates of the benefits from health research is that health research is supported by a broad range of public and charitable funders working alongside the pharmaceutical industry, and thus details about the inputs into the system are not available in one place. Collaboration between these sectors are common, but each sector has its own strategic plans and policies through which funding is assigned. To co-ordinate activity across funders, with the aim of maximising impact, knowledge of the funding landscape (which research activities are funded, where and by which funder) is needed.
Funding organisations are acutely aware of the benefits of co-ordinating resources and supporting complementary, rather than competing, research. Enhanced coordination has the potential to identify new strategic investment opportunities, by highlighting areas of unmet need or prior under-investment.
A committed partnership between health research stakeholders that create and oversee cooperative ventures.
A mechanism to determine the nature of health research funding on a national level which can be replicated over time.
A common classification system to uniformly identify types of health research being funded across a highly diverse range of funder types and research portfolios.
In the United Kingdom, processes have been in place for the last decade to coordinate health research on a national scale, to the benefit of the global research effort. This process was begun in 2004, with the establishment of the United Kingdom Clinical Research Collaboration (UKCRC) , a partnership between United Kingdom research funding bodies, the NHS, Government and other regulatory bodies, the biomedical industry, and patients. The UKCRC’s core aim was to “re-engineer the clinical research environment in the UK, to benefit the public and patients by improving national health and increasing national wealth” .
Part of this remit included the development and application of the Health Research Classification System (HRCS) , a bespoke system to analyse the United Kingdom’s health research landscape. Over the last decade, the HRCS has been used consistently within the United Kingdom, culminating with the publication of the third quinquennial analysis in August 2015. We are therefore now presented with the unique opportunity to show how the development of the HRCS and its application within the United Kingdom has influenced funding policies over the past 10 years. In particular, we wish to discuss how the collaboration between different organisations to sharing funding data has changed the nature of United Kingdom health research, with implications not just for the future of the country’s science base but for applications of classification systems as policy tools on a global scale.
The Health Research Classification System
In 2004, the UKCRC, via a dedicated secretariat, both developed the HRCS and conducted the first United Kingdom-wide analysis. The HRCS is a two-dimensional coding system, where each award is coded based on both the disease of focus (‘Health Category’) and type of research undertaken (‘Research Activity’). Health Categories are built from the WHO International Classification of Diseases , whilst Research Activities are developed from the Common Scientific Outline , originally developed by the United States National Institutes of Health National Cancer Institute and now in use by the International Cancer Research Partnership. The combination of the two coding arms allows a full breadth of coverage across all types of health research.
Data collection, coding and analysis
The elements of each individual United Kingdom Health Research Analysis are explained in more detail within the published reports . Here, we present a brief summary of each report’s methodology, which highlights the key details, the developments made and changes in practice from 2004/2005, through 2009/2010 and to 2014. Further information is also available in our Additional file 1: Supplementary methodology.
All three analyses required funders to submit award data via a common dataset of information consisting of a small amount of simple award information, namely basic Principle Investigator (PI) details such as Institute and Location, award type, amount and duration, alongside the award title and abstract, required for coding. The first United Kingdom Health Research Analysis (2004/2005)  brought together the 11 largest United Kingdom research organisations providing 9901 awards to a central database of funders’ research portfolios. The second analysis (2009/2010) comprised 12 research organisations providing 11,482 awards and the third analysis (2014) contained 17,021 awards from 64 research organisations.
To provide HRCS coding, the UKCRC Secretariat provided a complete classification check for the first analysis with each award independently coded twice (“dual coded”) then reviewed and standardised for inclusion in future HRCS training literature. Subsequent analyses relied on internal staff trained in HRCS to provide coding for awards, or via the use of dedicated external independent coders (“contract coders”). The dual coded quality control (QC) process was absent from the 2009/2010 analysis, but was replicated in the 2014 analysis on over 30% of awards.
Analysis results: 2004/2005 to 2014
Funding distribution by research activity for United Kingdom Health Research Analyses in 2004/2005, 2009/2010 and 2014
HRCS Research Activity Group
Difference in 2014 (£)
Difference in 2014 (%)
4 Detection and Diagnosis
5 Treatment Development
6 Treatment Evaluation
7 Disease Management
8 Health Services
The 2004/2005 analysis contributed to a landmark United Kingdom Government review of health research spending conducted by Sir David Cooksey in 2006 . This review was intended as a means to advise the Government on the best design and institutional arrangements for public health funding in the United Kingdom. Data from the HRCS analysis were key components in assessment of the current status of United Kingdom health research upon which suggestions for future funding policy could be made.
The key recommendation from the Cooksey Review was to strengthen translation of research into health and economic benefits. The Cooksey report noted the UKCRC analysis showed two thirds of research funding is invested in basic science, and that, while the reviewers supported sustained funding in this area, they recommended “that future increases in funding should be weighted towards translational and applied research until a more balanced portfolio is achieved” .
Using the 2004/2005 analysis as baseline, the second United Kingdom Health Research Analysis (2009/2010) showed that funding for health research from the United Kingdom public and charity sectors had increased by 50% in real terms, with £1.77 billion in real terms spend accounted for. An overall increase in total spend meant that every research activity saw a real terms increase in funding, however, the proportion spent on ‘Underpinning’ and ‘Aetiology’ fell (by 6% and 2.9%, respectively) in favour of increases in the remaining six groups, particularly in the translational areas of ‘Detection and Diagnosis’ (+2.0%) and ‘Treatment Development’ (+2.1%).
In addition to assessment of HRCS classifications, both the 2009/2010 and 2014 reports included an estimation of total United Kingdom expenditure on health-relevant R&D using sources, such as the United Kingdom Office for National Statistics data on Gross Expenditure on Research and Development. The estimation in 2009/2010 was £9.28 billion, with 52% from the private sector, meaning the £1.77 billion included in the core analysis constituted approximately 40% of the total public/charity-funded health research. In comparison, the 2014 analysis estimation of total United Kingdom Health R&D expenditure was £8.5 billion with 48% from the private sector. Therefore, the £3.01 billion compiled for the 2014 analysis constituted approximately 91% of all public/charity-funded health research in the United Kingdom.
The third HRCS analysis for 2014 shows some growth in health research spend, but at a greatly reduced rate; the Compound Annual Growth Rate (i.e. the mean annual growth rate), was 4.8% over the 10 years of this analysis period (2004 to 2014), but was 8.2% in the first 5 years (2004 to 2009) and only 1.4% in the second 5 years (2009 to 2014); substantially lower than the United Kingdom growth in GDP or growth in the consumer price index, which had a 2% and 2.6% Compound Annual Growth Rate,b respectively, over the same period. This low real-terms growth in expenditure over the last 5 years is consistent with data from the Association of Medical Research Charities in 2010/2011  and 2013/2014 , and the United Kingdom Government decision to provide level funding for research via the research councils in 2010 . In examination of the research activity distributions, we saw a 5 year real-terms decrease in funding for ‘Underpinning’ and ‘Aetiology’ (–£35 million and –£4.7 million, respectively), although total spend was still higher in real terms than in 2004/2005.
The proportion of spend for ‘Underpinning’ and ‘Aetiology’ had also decreased over this second 5 year period (–3.7% and –2.3%, respectively) meaning an overall reduction in proportional spending from 69% to 50% over the full 10 year reporting period. The decreases in proportional funding to basic research between 2009 and 2014 is counterbalanced with a further increase in proportional funding for ‘Prevention’ (+1.6%), ‘Detection and Diagnosis’ (+2.6%) and ‘Treatment Development’ (+1.4%). These changes are displayed in Fig. 1.
The increases over the last decade in ‘Detection and Diagnosis’ and ‘Treatment Development’ suggest that the initiatives recommended by the Cooksey Review and the subsequent strategic planning by Office for Strategic Coordination of Health Research have been realised. In the 10 year reporting period, both research activity areas received £126 million more in real terms spend and increased their share of overall spend by 3.5% and 4.7%, respectively. However, it is important to note that the Cooksey review focussed on the Government funding for health research, principally via the Medical Research Council and NIHR. Charitable funders support more than 40% of both ‘Detection and Diagnosis’ and ‘Treatment Development’ spending. Indeed, individual funder comparisons show the three largest United Kingdom charitable funders, British Heart Foundation, Cancer Research UK and Wellcome Trust, had the largest proportional gains in these two research activities. While the Cooksey Review recommended increased collaboration with other research stakeholders, these stakeholders have also changed their policies to improve translational research. For example, the Wellcome Trust’s Innovation Division, established in 2003, is specifically tasked with promoting translational health research .
Further application and development
In addition to the main HRCS analysis series, the classification system has been applied by other United Kingdom funders for internal reporting and further analyses. The full details of the classification system and data collected for the analyses are freely available via the HRCS website  and have been used extensively [22–26]. The majority of large funders also integrate HRCS coding into their portfolio management systems, allowing HRCS to be used for internal assessments and for answering policy questions and/or freedom of information requests. Data from HRCS coding features regularly in the Medical Research Council annual reports and appear on public award databases, including the Research Council United Kingdom’s Gateway to Research  and NIHR Evaluation, Trials and Studies (NETS) project portfolio .
In 2011, the European Medical Research Councils (EMRC, now SRG-MED) and European Science Foundation (ESF) compared a range of research classification systems, including OECD Frascati, Medical Subject Headings (MeSH), Australian and New Zealand Standard Research Classification and United States National Institutes of Health Research, Condition and Disease Categorization (RCDC) system . The EMRC and ESF recommended system was HRCS, with the suggestion for cross-Europe adoption as a portfolio analysis tool , particularly as there was interest in performing joint European analyses to comment on policies aimed at development of the European Research Area. The HRCS has since been trialled or adopted internationally in Ireland, Sweden, Norway, Switzerland, Canada, Hong Kong and Singapore.
Classifying award data
Categorisation of research awards is a pre-requisite for monitoring funding portfolios and allows future planning of new initiatives and strategies. Fundamental to any organisation that funds research is the ability to answer questions about what they have funded and where. As a result of this business need many research organisations use bespoke internal systems to classify award data. The HRCS could be considered just one example amongst many classification approaches and, while it has been successfully implemented in the United Kingdom, its usage and suitability for other organisations will vary depending on the research foci, funding organisations and countries involved.
There are, however, two key criteria which gives the HRCS the potential to become more widely accepted for health research. Firstly, the HRCS was adapted from pre-existing, international classification systems (i.e. International Classification of Diseases 10 & Common Scientific Outline) to ensure coverage of a full range of diseases and research activities and to allow alignment with other systems that use or are based on these systems (such as WHO Global Burden of Disease DALY data , or NHS England programme spend data ). However, while other classification systems, like MeSH and RCDC, use extensive medical research thesaurus terms, HRCS codes were specifically restricted with the explicit aim to be used at a higher aggregate level and be more useful for strategic national analysis. The design of the HRCS as a landscaping tool can lead to a perception that it lacks granularity. It is true that a more nuanced method is required to segregate within HRCS Health Categories; for example, to separate studies of Alzheimer’s from the overarching HRCS Health Category of ‘Neurological’. However, the additional costs in staff time to apply further levels of coding to a broad landscaping analysis is considerable and somewhat defeats the purpose of maintaining classifications at the wider strategic level. Indeed, it is the principle of universal application with restrained classification choices that is the greatest strength of the HRCS, hence the recommendation by the EMRC/ESF above other comparator classification systems.
Secondly, the HRCS analysis demonstrated that a small number of data fields for each award (i.e. Title, Abstract, Start & End Dates, Value, Location) are sufficient for a nationwide assessment of health research funding and can be successfully implemented by a diverse collection of research organisations for mutual benefit. This approach was feasible in practice and could be used both to monitor the effect of policy changes within individual organisations and their cumulative effect on the national funding strategy.
Costs and benefits of health research reporting
Management of the UKCRC exercise depends on a number of components. Firstly, sufficient resources need to be available to initiate, manage, and follow-up the analyses. It is difficult to accurately estimate the full cost of the three UKCRC analyses as resources have been contributed across a number of organisations and the management of the report has changed considerably in the last 10 years of reporting. The first report (2004/2005) required substantial support, including significant time taken to convert grant details held on paper to electronic records, and a full QC exercise of all coding. The second report (2009/2010) included more detailed analysis, such as assessment of investment in infrastructure and estimation of total United Kingdom health research expenditure. However, the second analysis did not include a dedicated project management resource to co-ordinate work across a large number of funding agencies, and did not include any dual coding of awards for QC. The third analysis in 2014 engaged a part-time project manager, involved more funders, more awards, a larger proportion of coding was performed internally (rather than contracted out) than previous analyses, and a third of awards were dual coded for QC purposes.
Breakdown of estimated costs for United Kingdom Health Research Analysis reporting
No. of Awards
Dedicated Costs (staff, contract coding, etc.)
Internal Funder Estimates (Cost)
Approximate Report Cost Total
Total Cost per Award
It is important to note that these project costs, and the costs associated with changes in funder practices to establish routine coding, may be somewhat off-set by the re-use of data for internal reporting, informing on other funding policies and benchmarking for individual intra-funder award schemes. The 2014 analysis has already proven more useful than the 2009/2010 analysis, simply because it was possible to complete it sooner after the end of 2014, and so the information within the report had greater immediate currency. Furthermore, the value of the landscaping reports themselves will continue to grow with the full underlying datasets made freely available for re-use. Despite these long-term benefits, reduction of costs is an important consideration for the future of HRCS. One potential resolution to this issue would be the development of automated coding, and at the time of writing the company UberResearch  was testing a promising approach for this. Using computer algorithms to apply HRCS would clearly reduce the significant human resources needed for routine coding, allowing for larger and/or more frequent analyses. However, the nuances of interpreting project descriptions and the language used to define project aims are likely to continue to require human input to ensure such algorithms can be adapted to changes in the language used in abstracts and developments in research fields. Unsurprisingly, it is clear that human coders vary in the way that they apply HRCS categories, despite minimising this variability through training and guidance. This variation can be corrected in part by coding awards multiple times, the objective of the QC process; however, as noted above, this adds significantly to the costs of the exercise. Automated coding has the potential to offer a consistent and very low cost coding approach, which could be adapted and retrospectively applied as requirements for coding change over time.
Availability of portfolio information
The ability to obtain the necessary data on the awards funded from a large range of different research organisations is essential for landscaping analyses. In the past, the only way to obtain this information was to approach each funding organisation. Funders are beginning to provide details of their health research portfolios openly available in a form that can be systematically re-used at the award level. Within the United Kingdom, several funders now make this information publicly available as a way of accounting for the support they receive from the public. Yet, many research funders are still hesitant in making all award information publically available.
It is important to note that details of the studies supported by the private sector, which constitutes nearly half the United Kingdom’s health research and development expenditure, are not available. Due to issues of commercial sensitivity this information is unlikely to ever be publicly available at the level of individual projects. Thus, even an established landscaping project such as the UKCRC analysis series capturing 91% of public/charitable funding is still only representative of half (52%) of national health research spending .
Given the clear benefits of better coordination of health research, there are efforts being made to compile public and charity funding information at national and international levels. International strategic collaborations such as the Heads of International Research Organisations  and the WHO’s World Health Assembly , aim to promote national, regional and global coordination of health research. In addition, efforts have already been made to establish a comprehensive international dataset of awards such as the WHO global health research and development observatory  and National Institutes of Health World RePORT system.c Just as the United Kingdom HRCS health research analysis has proved highly beneficial, more comprehensive international databases of funding data would be invaluable to funding organisations and researchers working in the field of health research policy. There may also be benefits to the wider biomedical research community. Submitting articles for publication, compiling online CVs, completing institutional or other records of output and other administrative activities is time consuming, therefore having a single national or international record of ‘who funds what where’ in which grant/award details can be looked up, selected and transferred, rather than re-entered, would be of considerable importance.d Similar to DOIs for research papers and ORCIDs for researchers, a single source of grant identifiers would support funders and researchers alike to align the outputs of research with the funding that supports it.
From our experience with the UKCRC report series, we believe that funders are increasingly seeing the benefit to sharing their portfolio data, both to their individual organisations, and collectively for strategy development at a national level. Open data from funders would allow easier benchmarking between research organisations, easier comparison of research strategies and maintaining competitiveness. In addition, research funders could identify potential partner organisations with similar or complimentary interests, more readily identify appropriate peer reviewers, and streamline researcher recruitment and funding assessments. Furthermore, shared, comparable award information will also benefit researchers, providing invaluable data for ‘science of science policy’ research and a key resource to link research funding with researcher outputs.
aFor comparison purposes, previous analysis figures are expressed in real terms (i.e. 2014 prices) using the UK GDP deflator data as at December 2014. Full details of the calculations can be found in the Methods chapter. https://www.gov.uk/government/statistics/gdp-deflators-at-market-prices-and-money-gdp-december-2014-quarterly-national-accounts. Accessed 10 June 2015.
bGDP and CPI data based on CAGR calculations from ONS GDP between 2010 and 2014; https://www.ons.gov.uk/economy/grossdomesticproductgdp/timeseries/abmi and http://webarchive.nationalarchives.gov.uk/20160105160709/http://ons.gov.uk/ons/datasets-and-tables/data-selector.html?cdid=D7BT&dataset=mm23&table-id=1.1, respectively, Accessed 05 Mar 2016.
cWorld RePORT is an illustrative mapping database system designed by the US National Institutes of Health (NIH) to facilitate communication and coordination of biomedical research funded by major government agencies and philanthropic organizations around the world. https://worldreport.nih.gov/index.cfm. Accessed 05 Mar 2016.
dServices such as the Europe Pub Med Central grant finder http://europepmc.org/grantfinder, or the ÜberWizard for ORCID provided by UberResearch Ltd. http://www.uberresearch.com/orcid-wizard/ are examples of the first datasets/processes to address part of this issue.
DALY, Disability Adjusted Life Years; EMRC, ESF Scientific Review Group for the Biomedical Sciences (SRG-MED) (formerly European Medical Research Councils, EMRC); ESF, European Science Foundation; HRCS, Health Research Classification System; MeSH, Medical Subject Headings; NHS, National Health Service; NIHR, National Institute for Health Research; NPRI, National Prevention Research Initiative; QC, Quality Control; RCDC, Research, Condition and Disease Categorization; UKCRC, United Kingdom Clinical Research Collaboration
The authors would like to thank the members of the Health Research Analysis Forum and the United Kingdom Clinical Research Collaboration for their support in production of the United Kingdom Health Research Analysis report series. These form the basis of this article and constitute the contribution from numerous coders, data analysis and portfolio managers across the 64 research organisations that have participated in this report series. Without their hard work and dedication the report series and this article would not be possible. The authors would also like to thank Andrew Speakman and Anna Smith, who have provided consultation, contract coding and training on the HRCS over the past 10 years.
JGC was the project manager for the United Kingdom Health Research Analysis 2014 and produced the draft of this manuscript. BJS provided support and intellectual input to 2009/2010 and 2014 analyses and this manuscript. ISV provided support and intellectual input to 2009/2010 and 2014 analyses, plus conceived and helped to draft the manuscript. All three authors have read and approved the final manuscript.
All three authors are employees of the Medical Research Council United Kingdom. JGC is an Evaluation Officer (www.orcid.org/0000-0003-1860-9677), responsible for corporate reporting and projects. BJS is the Evaluation Programme Manager (www.orcid.org/0000-0002-4298-5499). ISV is the Director of Strategic Evaluation and Impact (www.orcid.org/0000-0002-9943-4989).
The authors declare they have no competing interests.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Scarborough P, Bhatnagar P, Wickramasinghe KK, Allender S, Foster C, Rayner M. The economic burden of ill-health due to diet, physical activity, smoking, alcohol and obesity in the UK: an update to 2006-7 NHS costs. J Public Health. 2011;33(4):527–35. doi:10.1093/pubmed/fdr033.View ArticleGoogle Scholar
- Government Office for Science. Tackling obesities: future choices – project report (2nd edition). Published online by Government Office for Science. 2007. https://www.gov.uk/government/publications/reducing-obesity-future-choices. Accessed 03 July 2015.
- Health & Social Care Information Centre. Health Survey for England, 2013: Health, social care and lifestyles: summary of findings. Published online by Health & Social Care Information Centre. 2014. http://www.hscic.gov.uk/catalogue/PUB16076/HSE2013-Sum-bklet.pdf. Accessed 03 July 2015.
- Dementia UK: update. http://www.alzheimers.org.uk/dementiauk. Accessed 15 Oct 2015.
- Sussex J, Feng Y, Mestre-Ferrandiz J, Pistollato M, Hafner M, Burridge P, Grant J. Quantifying the economic impact of government and charity funding of medical research on private research and development funding in the United Kingdom. BMC Med. 2016;14:32.View ArticlePubMedPubMed CentralGoogle Scholar
- Hinrichs S, Grant J. A new resource for identifying and assessing the impacts of research. BMC Med. 2015;13:148. doi:10.1186/s12916-015-0364-x.View ArticlePubMedPubMed CentralGoogle Scholar
- Haskel J, Hughes A, Bascavusoglu-Moreau E. The economic significance of the UK science base: a report for the campaign for science and engineering. Published by the UK Innovation Research Centre. 2014. http://www.sciencecampaign.org.uk/resource/UKScienceBase.html. Accessed 10 June 2015.
- Glover M, Buxton M, Guthrie S, Hanney S, Pollitt A, Grant J. Estimating the returns to UK publicly funded cancer-related research in terms of the net value of improved health outcomes. BMC Med. 2014;12:99. doi:10.1186/1741-7015-12-99.View ArticlePubMedPubMed CentralGoogle Scholar
- UK Clinical Research Collaboration. http://www.ukcrc.org/about-the-ukcrc/what-is-the-ukcrc/. Accessed 06 May 2016.
- UKCRC Health Research Classification System. http://www.hrcsonline.net/. Accessed 10 June 2015.
- WHO International Statistical Classification of Diseases and Related Health Problems (10th Revision) - Version for 2004. http://apps.who.int/classifications/apps/icd/icd10online2004/fr-icd.htm. Accessed 06 October 2015.
- International Cancer Research Partnership Common Scientific Outline – Version 1. Updated to current version (v2) in April 2015. https://www.icrpartnership.org/CSO.cfm. Accessed 06 October 2015.
- All three UK Health Research Analyses are available via the HRCS website. http://www.hrcsonline.net/pages/reports. Accessed 03 May 2016.
- UK Clinical Research Collaboration. UK Health Research Analysis 2004/05. Published online by UKCRC. http://www.ukcrc.org/wp-content/uploads/2014/03/Health-Analysis-Report-FULL-final.pdf. Accessed 10 June 2015.
- WHO Global Burden of Disease DALY Estimates. 2002. http://www.who.int/healthinfo/global_burden_disease/estimates/en/index2.html. Accessed 10 June 2015.
- Cooksey D. A review of UK health research funding. Published with the permission of HM Treasury on behalf of the Controller of Her Majesty’s Stationery Office. 2006. ISBN-10: 0-11-840488-1. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/228984/0118404881.pdf. Accessed 06 October 2015.
- Association of Medical Research Charities. AMRC annual report 2010/11: Maximising impact through collaboration. 2011. http://www.amrc.org.uk/sites/default/files/doc_lib/2011%20AMRC%20Annual%20review.pdf. Accessed 10 June 2015.
- Association of Medical Research Charities. AMRC annual review 2013/14: Charities at the heart of UK life sciences. 2014. http://www.amrc.org.uk/sites/default/files/doc_lib/AMRC-annual-review-2013-14.pdf. Accessed 10 June 2015.
- Department of Business, Innovation and Skills. The allocation of science and research funding 2011/12 to 2014/15: Investing in world class science and research (December 2010). 2010. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/422477/bis-10-1356-allocation-of-science-and-research-funding-2011-2015.pdf. Accessed 10 June 2015.
- NPRI Report Group. National Prevention Research Initiative (NPRI): Initiative outcomes and future approaches. 2015. Published online by the Medical Research Council. https://www.mrc.ac.uk/publications/browse/national-prevention-research-initiative-npri-report-2015/. Accessed 05 June 2016.
- Wellcome Trust Innovations (main page). https://wellcome.ac.uk/what-we-do/teams/innovations-team. Accessed 10 June 2015.
- UK All-Party Parliamentary Group (APPG) on Global Health. The UK’s Contribution to Health Globally: Benefiting the country and the world. 2015. http://www.appg-globalhealth.org.uk/download/i/mark_dl/u/4009611296/4622063799/The%20UK’s%20contribution%20to%20health%20globally_FULL.pdf. Accessed 10 June 2015.
- Kinge JM, Roxrud I, Vollset SE, Skirbekk V, Røttingen JA. Are the Norwegian health research investments in line with the disease burden? Health Res Policy Syst. 2014;12:64. doi:10.1186/1478-4505-12-64.View ArticlePubMedPubMed CentralGoogle Scholar
- Medical Research Council. Review of UK mental health research: report of strategic review group 2010. http://www.mrc.ac.uk/publications/browse/review-of-mental-health-research/. Accessed 10 June 2015.
- Nicolau I, Ling D, Tian L, Lienhardt C, Pai M. Research questions and priorities for tuberculosis: a survey of published systematic reviews and meta-analyses. PLoS ONE. 2012;7(7):e42479. doi:10.1371/journal.pone.0042479.View ArticlePubMedPubMed CentralGoogle Scholar
- Curran B, Barrett R. Outputs, outcomes and impacts arising from the Health Research Board’s 2000-09 grants portfolio. 2014. Published by the Health Research Board, Dublin, Ireland. ISBN: 978-1-903669-20-4. http://www.hrb.ie/uploads/tx_hrbpublications/Outputs__outcomes_and_impacts_arising_from_the_HRB_s_2000-09_grants_portfolio.pdf. Accessed 10 June 2015.
- Research Council UK. Gateway to research funding database. 2013. http://gtr.rcuk.ac.uk/. Accessed 10 June 2015.Google Scholar
- National Institute of Health Research Evaluation, Trials and Studies funding database. 2013. http://www.nets.nihr.ac.uk/. Accessed 06 October 2015.
- ESF Science Policy Briefing. Health Research Classification Systems – Current Approaches and Future Recommendations. 2011. Published by the European Science Foundation. ISBN: 978-2-918428-52-7. http://www.esf.org/fileadmin/Public_documents/Publications/spb43_Health_Research_Classification.pdf. Accessed 10 June 2015.
- European Science Foundation. The European Science Foundation’s MED (formerly EMRC) calls for the common use of the Health Research Classification System across Europe. 2011. http://www.esf.org/media-centre/ext-single-news/article/the-european-science-foundations-emrc-calls-for-the-common-use-of-the-health-research-classificat.html. Accessed 10 June 2015.
- World Health Organization. Health statistics and information systems. Global Burden of Disease. http://www.who.int/healthinfo/global_burden_disease/gbd/en/. Accessed 05 June 2016.
- NHS Programme Budgeting. https://www.england.nhs.uk/resources/resources-for-ccgs/prog-budgeting/. Accessed 05 June 2016.
- UberResearch. http://www.uberresearch.com/. Accessed 05 June 2016.
- Estimation of total UK health research expenditure is based on data on UK Gross Expenditure in Research and Development (GERD) provided by the Office for National Statistics. See the 2014 UKCRC report for more details.Google Scholar
- Viergever RF. Aid alignment for global health research: the role of HIROs. Health Res Policy Syst. 2011;9:12. doi:10.1186/1478-4505-9-12.View ArticlePubMedPubMed CentralGoogle Scholar
- World Health Assembly. Resolution WHA66.22: Follow up of the report of the Consultative Expert Working Group on Research and Development: Financing and Coordination. Geneva: World Health Organisation; 2013. http://www.who.int/phi/resolution_WHA-66.22.pdf?ua=1. Accessed 03 May 2016.