Skip to main content

Measuring research impact in Australia’s medical research institutes: a scoping literature review of the objectives for and an assessment of the capabilities of research impact assessment frameworks



Realising the economic potential of research institutions, including medical research institutes, represents a policy imperative for many Organisation for Economic Co-operation and Development nations. The assessment of research impact has consequently drawn increasing attention. Research impact assessment frameworks (RIAFs) provide a structure to assess research translation, but minimal research has examined whether alternative RIAFs realise the intended policy outcomes. This paper examines the objectives presented for RIAFs in light of economic imperatives to justify ongoing support for health and medical research investment, leverage productivity via commercialisation and outcome–efficiency gains in health systems, and ensure that translation and impact considerations are embedded into the research process.

This paper sought to list the stated objectives for RIAFs, to identify existing frameworks and to evaluate whether the identified frameworks possessed the capabilities necessary to address the specified objectives.


A scoping review of the literature to identify objectives specified for RIAFs, inform upon descriptive criteria for each objective and identify existing RIAFs. Criteria were derived for each objective. The capability for the existing RIAFs to realise the alternative objectives was evaluated based upon these criteria.


The collated objectives for RIAFs included accountability (top-down), transparency/accountability (bottom-up), advocacy, steering, value for money, management/learning and feedback/allocation, prospective orientation, and speed of translation. Of the 25 RIAFs identified, most satisfied objectives such as accountability and advocacy, which are largely sufficient for the first economic imperative to justify research investment. The frameworks primarily designed to optimise the speed of translation or enable the prospective orientation of research possessed qualities most likely to optimise the productive outcomes from research. However, the results show that few frameworks met the criteria for these objectives.


It is imperative that the objective(s) for an assessment framework are explicit and that RIAFs are designed to realise these objectives. If the objectives include the capability to pro-actively drive productive research impacts, the potential for prospective orientation and a focus upon the speed of translation merits prioritisation. Frameworks designed to optimise research translation and impact, rather than simply assess impact, offer greater promise to contribute to the economic imperatives compelling their implementation.

Peer Review reports


The economic potential of research institutions, including medical research institutes (MRIs), remains high on the policy agenda for many Organisation for Economic Co-operation and Development (OECD) nations [14]. As a consequence, the question of how to measure and assess returns from investment in health and medical research (HMR) remains a highly policy-relevant issue. Research impact assessment frameworks (RIAFs) provide a conceptual framework and methods against which the translation and impact of HMR can be assessed. Reviews by the Canadian Academy of Health Sciences (CAHS) [5], Brutscher [6], Banzi and Moja [7], and Milat and Bauman [8] summarise in detail the form and characteristics of existing RIAFs. However, a review of this literature demonstrates that, despite the centrality of purpose in evaluation [9], the objective of assessment is rarely instructive of the form, method and content of these RIAFs.

Impact assessment of HMR research expenditure has been elevated on the policy agenda through three inter-related economic imperatives:

  1. (1)

    Scarcity – Largely as a result of stimulatory fiscal policy during the global financial crisis, general government debt as a percentage of gross domestic product through 2014, remained markedly higher than pre-crisis levels for the majority of OECD nations, including Australia [10]. The accompanying political pressure to manage this debt, while simultaneously stimulating economic growth, heightens the justification necessary for on-going public expenditure in HMR, against competing budget priorities.

  2. (2)

    Productivity – Health service budgets have been cut or frozen substantially in many OECD nations, including Australia, intensifying the demand for innovative research solutions that improve health outcomes with the same or less public expenditure [11]. In the commercial realm, economic growth is increasingly reliant upon a knowledge-intensive industry, and policymakers are keen to optimise commercial innovations in medical services, pharmaceuticals and medical devices [12]. Citing Australia’s strong research capability, the McKeon Strategic Review of Health and Medical Research [13] identified potential productivity gains in both commercial and non-commercial arenas founded upon opportunities to leverage HMR and its supporting ecology. As a consequence, the requirement to generate economic productivity via greater commercial returns and cost-effective improvements to health outcomes represents a second imperative for impact assessment.

  3. (3)

    Efficacious, effective and cost-effective research outcomes – The third economic imperative arises from within HMR. An increasing level of research on HMR has highlighted numerous areas of unproductive expenditure via practices ranging from poorly-informed research questions and weak study design to irreproducible outcomes and failed implementation [1417]. Chalmers and Bracken [14] estimate that, globally, $240 billion of annual biomedical research expenditure is wasted. Their research illustrates the potential to improve productive health outcomes by ensuring that translation is embodied throughout the research process.

We contend that these imperatives necessitate prioritisation of a different set of objectives, with according implications for the impact assessment of Australia’s MRIs.

Australia supports approximately 70 independent MRIs, which collectively facilitate the investigations of approximately 10,100 researchers [18]. The Institutes’ relationship with researchers varies from direct employment to facilitation of research conducted by employees of affiliated organisations, such as local health districts, universities or the private sector. The breadth of HMR conducted within Australia’s MRIs is extensive, ranging across populations, disease, policy, practice and medical products [19], and from basic science through to public health. The Institutes receive funding through competitive grants, fellowships and programs, state government infrastructure programs, grants from foundations and trusts, and commercial returns from intellectual property, contracted research and community donations. In addition to preferential taxation status, government support comprises approximately half of this funding [18]. To justify this support from government and the community, Australia’s MRIs continue to progress their approach to impact assessment. This research seeks to inform upon the development of assessment frameworks for MRIs.

The first aim of this paper was to list the stated objectives for RIAFs. The second aim sought to identify existing frameworks. The final aim sought to evaluate whether the identified frameworks possessed the capabilities necessary to address the specified objectives.

The definitions adopted for this paper include:

  • Research activity – Activities necessary to conduct medical and health research, where research is defined as “creative work undertaken on a systematic basis in order to increase the stock of knowledge, including knowledge of man, culture and society, and the use of this stock of knowledge to devise new applications” [20].

  • End-users – Agents along the pathway to impact that utilise the research outputs, including members of the community, the public sector, industry and other researchers. As such, this definition includes both interim and final users.

  • Research outputs –The knowledge deliverables produced by research activity, e.g. peer-reviewed papers, presentations, contributions to collaborative endeavours, guidelines, education, prototypes, etc.

  • Research outcomes/Interim impacts – Research outputs transform to research outcomes/interim impacts following utilisation by an end-user along the pathway to final impact.

  • Final impacts – The demonstrable effect from the flows of knowledge between basic, patient and population-orientated research, and clinical trials, that improves human health and quality of life, and generates benefits for society, the economy, culture, national security, public policy, or the environment [21].


The methods for this study are summarised in Fig. 1. We undertook a scoping review of the literature [22]. The review comprised a systematic search of a finite number of key publication databases, a rigorous review of the grey literature and extensive hand searching of cited references [23, 24] (Fig. 2).

Fig. 1
figure 1

Flow diagram – Methods

Fig. 2
figure 2

Flow diagram – Literature selection protocol [5962]. *Note: Excludes reviews presented prior to an included framework

The literature search strategy included a search of peer-reviewed academic literature held within Scopus and grey literature referenced within OpenGrey, WHOLIS (Who Database), and The databases were searched using the following strategy:

  • KEY ((translation* W/1 (research OR knowledge)) OR “knowledge mobili?ation*” OR “research into practice” OR “translation to health application*” OR “translation to patient*” OR “translation to health practice*” OR “translation to population health impact” OR “research impact” OR “knowledge into practice” OR “populari?ation of research” OR “research generated knowledge”) AND

  • TITLE-ABS-KEY (metric* OR framework* OR payback OR “social return” OR sroi OR measure* OR “financial return*” OR “political impact” OR “policy impact*” OR “Social impact*” OR bibliometrics OR econometrics OR “economic evaluation*” OR “cost effectiveness” OR “cost benefit analysis”)

The search was limited to studies published in English from January 2005 to June 2015. Studies not focussed upon medical or health research were excluded. Only papers that referred to theory, a conceptual model or framework pertaining to the evaluation of research outcomes were included. Studies that solely examined bibliographic impact were excluded. Frameworks to encourage best practice through guidelines/checklists and assessments focussed upon a singular medicine or health research area without reference to the utility of the framework were also excluded.

The results of the search strategy and the exclusion criteria are summarised in Fig. 2. In summary:

  • An initial review of abstracts against the inclusion criteria in the databases of academic publications found 1971 abstracts.

  • Searches of reference lists and the grey literature identified a further 67 documents.

  • The review of full papers and documents identified two reviews, 25 frameworks and 26 documents containing relevant information.

  • A number of frameworks represented minor variations upon an established framework and were excluded. For example, the Banzi and Moja [7] framework was considered similar to the original CAHS [5] framework, and that of Rubio and Schoenbaum [25] similar to the Trochim and Kane [26] framework for the purpose of this analysis.

The first aim was realised through a thematic synthesis of the literature to identify specified objectives and common criteria. The objectives were identified independently by two researchers. Criteria for each objective were derived and independently reviewed by a second researcher. The existing RIAFs were also identified from the literature by two researchers. For this purpose, a RIAF was defined as a conceptual model/framework and/or a collection of evidence designed to assess the translation or impact of HMR beyond traditional academic outcomes.

The second aim was realised through identification of existing research impact assessment frameworks from the literature search. The final aim was realised through an evaluation of the respective capabilities of the identified frameworks. Two researchers independently assessed the capacity of each RIAF to meet the alternative objectives based upon the descriptive criteria. The evaluation results were categorised according to the following exclusive definitions:

  • Yes/No – The RIAF could/could not meet the criteria specified for each respective objective;

  • Partial – The RIAF could meet the criteria for the respective objectives, but was not relevant to the full spectrum of HMR; or

  • Possible – The RIAF is capable of meeting the specified criteria for the respective objectives with modest adaptions

Given that the evaluators possessed significant knowledge regarding RIAFs and that guesswork was unlikely, a percentage agreement statistic was used to test inter-rater reliability. Following the initial review, inconsistencies were discussed and a mutually-agreed outcome determined. Unresolved differences are presented in the results.


Objectives for RIAFs

The thematic analysis of the literature identified eight categories under which the objectives for a RIAF could be grouped (Table 1), namely accountability (top-down); transparency/accountability (bottom-up); advocacy; steering; value for money; management/learning and feedback/allocation; prospective orientation; and speed of translation. Accountability for the consumption of resources and the consequences of HMR represents the most common objective for impact assessment [6]. However, the question of ‘to whom is the research accountable’ generates different implications. A RIAF that provides accountability for aggregate HMR expenditure on a broad national or sectoral scale, may provide sufficient information for government or national funders, but insufficient information for accountability by individual institutions or research programs. An objective to provide transparency [1] is closely aligned with accountability at a more granular level. Transparency to research activity, outputs and outcome steps along a pathway to impact provides accountability for these steps and consequently, the potential to improve outcomes. Hence, for the purpose of the subsequent evaluation, these objectives were separated into accountability (top-down) and transparency/accountability (bottom-up) with according criteria.

Table 1 Categories of objectives identified for research impact assessment frameworks (RIAFs)

Advocacy was also commonly presented as an objective for research assessment [5]. While the audience for advocacy includes politicians, funders, policymakers, philanthropists, researchers and the wider community, the implications for RIAFs remain largely consistent. Consequently, the criterion adopted for advocacy reflects the ability of a RIAF to demonstrate capability to relevant stakeholders.

The capacity for a framework to steer research to address specific HMR goals represents a less common objective [6, 27]. All impact frameworks steer research towards societal benefits, but not all are designed to align the research agenda towards a specific target, e.g. improving the diagnosis, treatment and care of people with dementia. For example, a framework that solely utilises a case study methodology is ill-placed to realise this objective [28]. In the subsequent evaluation, the capacity for a framework to align the research agenda to a specific target represents the criterion for a Steering objective.

Value for money is commonly inferred as an objective for research assessment, but rarely raised explicitly in the literature [29, 30]. It is possible to define value for money as the proportion of non-monetised outcomes to inputs (resources consumed). However, if the information from a RIAF seeks to encourage productivity, broader comparison through standardisation into utility measures, such as Quality-Adjusted Life Years, other comparable health outcomes, monetised benefits or similar would be necessary [31]. The criterion for the evaluation reflects this requirement.

Learning and feedback represents a common objective in the literature, while general management was occasionally specified. Funding allocation represents another related, but less common objective [32]. Given that financial allocation is dependent upon sufficient management/learning and feedback information, these three objectives were collated. The criterion determined for the evaluation reflected the capacity for the information produced by the RIAF to inform subsequent strategic management decisions, such as fund allocation, within or between research organisations.

The final two objectives are less commonly identified in the literature. Evaluating the United States National Institute of Health Clinical and Translational Science Awards funding, Trochim and Kane [26] specify the length of time for research translation as a definitive objective. An objective to improve the speed of translation seeks to expedite health improvements and closely aligns with the economic rationale of rates of return, in this case from HMR investment. To realise improvements in the length of time for translation, the assessment framework requires three elements. Firstly, identification of the intended final health impact and where the research lies along the pathway to this potential impact. Secondly, the inclusion of process metrics that enable individual actors (researchers, teams) to be accountable for steps along the pathway to final impact. Thirdly, the inclusion of a logic model component that necessitates ‘use’ for an outcome to be acknowledged as generating an interim impact. The criteria to assess whether a framework has the capacity to pro-actively improve the speed of translation are subsequently determined by these qualities.

The objective of prospective orientation of research is explicitly raised by the Hunter Medical Research Institute Framework to Assess the Impact from Translational Health Research (HMRI FAIT) framework [21] as prospective implementation supports the use of performance monitoring and feedback. This objective is closely aligned with the speed of translation, as productive adjustments can be made prior to resource expenditure [21]. However, these themes have been kept discrete as an objective to improve the speed of translation may imply requirements beyond prospective implementation and vice versa. The criteria for this latter objective reflected the capacity for a framework to be implemented prospectively, whether it compelled prior determination of the anticipated final impact and whether it allowed for prior scrutiny of the anticipated steps towards this goal via process metrics.

Identification of existing RIAFs

The review identified 25 RIAFs that met the literature inclusion criteria (Table 2). While inclusion was narrowly focussed upon frameworks pertaining to the evaluation of research outcomes, the focus, conceptual form and methods utilised varied markedly. The breadth of methods utilised by these frameworks include pure metrics, such as the engagement and impact framework proposed by Australian Academy of Technology and Engineering [33], pure economic models [34], and mixed methods utilised by CAHS [5], through to the peer-reviewed case studies of the United Kingdom’s Research Excellence Framework (REF) [28, 35]. Some frameworks are focussed upon particular aspects of translation, such as that of Landry and Amara [36], while others seek to address the research process across the translation spectrum [26, 37]. Collected reviews of the form and content of these frameworks have been published elsewhere [68, 38].

Table 2 Capacity for existing research impact assessment frameworks to address specific objectives

Framework evaluation

This study sought to evaluate the capacity of the identified frameworks to realise the criteria specified for each objective; the results of this evaluation are summarised in Table 2. The initial percentage agreement statistic for the classification of each framework measured 62.5% between the two independent researchers. Following discussion of the differences and reclassification, the agreement statistic measured 92%. Where differences remain unresolved, both responses are tabulated. Differences largely reflected moderate variations in the interpretation of the capabilities of the conceptual models. Note that some frameworks are capable of realising objectives beyond those specified in their development.

Accountability (top-down)

The majority of existing RIAFs met the criteria to provide information that could be utilised to provide holistic (top-down) accountability for government, funding bodies or community stakeholders. Frameworks classified as ‘partial’ provided few aggregations, e.g. Six-sigma/lean model, or limited breadth, e.g. Research Utilization Framework, the Australian Research Council’s Excellence in Research Australia (ARC ERA) impact measures.Footnote 1 The form of this information varies across peer-reviewed qualitative studies of impact [36, 39, 40], exclusively quantitative analyses [26, 33, 34, 4144] and numerous mixed method assessments [5, 21, 27, 4547].

Transparency/accountability (bottom-up)

Under this criterion, at least 18 frameworks provide sufficient transparency to determine a level of (bottom-up) accountability to a range of stakeholders. Frameworks, such as the Economic Impact Analysis (EIA), provide no transparency below the national or sectoral scale of analysis and consequently cannot incentivise research activity [41]. The Australian Academy of Technology and Engineering’s Research Engagement for Australia framework provides no transparency to non-commercial/non-financial impacts. It was consequently categorised as ‘partial’, given the limited incentive provided to drive economic productivity within the public health or not-for-profit sectors [33].


Nineteen of the frameworks reviewed provide information suitable for advocacy and a further three frameworks are partially suitable. Only the Balanced Scorecard and Six-sigma/lean models are potentially limited, due to their focus upon performance indicators at the expense of aggregate capability. Frameworks that incorporate a case study method potentially have an advantage for advocacy purposes. The narrative can assist the comprehension of specialist users (policymakers, clinicians), as well as non-specialists (politicians, funding bodies, philanthropists, the community), and potentially captures impacts missed by other methods [7]. Case studies are, however, limited for other objectives by selection, conceptualisation and reporting bias [40].


Steering the research agenda was explicitly raised as an objective for one framework [27] and one of the reviews [6]. All impact frameworks steer research, directly or indirectly, towards societal benefits. Whether a framework could align the research agenda towards a specific target, e.g. improving the diagnosis, treatment and care of people with dementia, represented the criteria for assessment. The Measurement of Research Impact and Achievement (MORIA) frameworkFootnote 2 provides a prospective assessment, where the research proposal could be designed and prospectively assessed against the realisation of the targets for tied funds [48]. The focus upon outcomes within the Weiss framework also suggests that a logic model approach could be readily adapted to this objective [49]. In contrast, some frameworks, such as ARC ERA, EIA and the REF, are designed for retrospective analysis and consequently lend themselves poorly to steering [28, 35, 41, 50]. Finally, a number of the frameworks could accommodate the pre-specification of a health ‘target’ [21, 46, 51, 52]. For example, the Decision Making Impact Model explicitly considers the source of the demand for research knowledge, from which impact assessment through the ‘user-pull’ method could be conducted [27].

Value for money

The capacity for the assessment frameworks to realise the value for money objective is mixed. Only eight frameworks definitively have the capacity to provide information to assess value for money. Most of these frameworks are relatively broad in scope and, consequently, include methods that could provide value for money assessments, e.g. economic assessment. It is assumed for this assessment that macroeconomic impact assessments [34, 41] only provide for international or disease burden comparison and are consequently classified as partial for the purpose of a value for money objective. Nearly half of the frameworks were categorised as ‘partial’ or ‘possible’, alluding to two factors. Firstly, there is a lack of clarity regarding the purpose and therefore for the definition of value for money. Secondly, ambiguities often remain with the question of ‘value for money to whom?’.

Management, learning, and feedback and allocation

The majority of frameworks met this criteria, albeit that the emphasis varies from the relative impact of research outputs [5, 44, 45, 51] to organisational aims, such as progress towards strategic goals [32, 53]. While the methodologies adopted within the frameworks varied, most provide the grounds to facilitate comparison, albeit that greater transparency assists comparison in the “doing, diffusion and impact of research within and across research fields” [40]. A number of the frameworks were utilised as the managerial basis for disbursement of research funds [1, 32, 39, 53].

Speed of translation

When evaluated against the specified criteria, very few frameworks are designed to optimise the speed of translation (Table 2). The Process Marker Model, the Research Utilisation Ladder and the Decision Making Impact Model were designed with the pathway to impact and end-users in mind [26, 27, 36]. The latter two are, however, limited by their focus solely upon final end-users of research. If imperatives, such as the lag to final impact [5, 28, 44] and sub-optimal research practices within HMR [1417], are to be addressed, then a framework requires a broader interpretation of steps in the process of research translation. The Balanced Scorecard represents another performance management framework that provides for steps along the pathway to impact, but fails to guide the critical link to usage at each step [42]. The Lean/Six-sigma models incorporate ‘customer’ needs, but favour technical and precisely quantifiable systems. The Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) model was developed for public health programs [54]. Consequently, while logic model components relating to the adoption, implementation and maintenance of research interventions emphasise usage, RE-AIM does not readily extend to similar aspirations for biomedical, clinical efficacy or health systems research. The University of Washington Institute for Translational Health Sciences Kellogg Logic Model – World Health Organization Health Services Assessment (ITHS KLM–WHO) model, fulfils the criteria, but the emphasis upon outputs and a passive approach to feedback does not provide for the pro-active acceleration of translation [47]. The characteristics of HMRI FAIT, the Process Marker Model and Translational Research Organizations Performance Model appear most capable of realising this objective. While limited in some respects, the Decision Making Impact Model, Lean/Six-sigma, RE-AIM and the Research Utilization Ladder also possess qualities that are informative for the realisation of this objective.

Prospective orientation of research

Similar to the speed of translation, the capacity for frameworks to realise an objective to prospectively orientate research is mixed (Table 2). Inflexible retrospective formats disqualify the existing ARC ERA, EIA, Matrix Scoring System and the Research Engagement for Australia [29, 33, 41, 50, 53]. The Health Services Research Impact Framework and the Research Impact Framework were designed partly to guide researchers in the prospective planning of research implementation [40, 51], but provide limited guidance regarding process metrics that align research to anticipated impacts. MORIA was developed with a consideration to ‘drive desirable behaviours’ [48]. The intended implementation of this framework at the grant review stage provides for the prior orientation of research to optimise productive research outcomes. However, MORIA was focussed upon the track record of the researcher, as opposed to the research process. Consequently, the specified metrics do not provide flexibility to tailor interim targets (process metrics) in line with individual pathways to impact. This stated, the track record provides an incentive for researchers to realise potential impacts.

Prospective implementation of the HMRI FAIT framework on a number of research programs, including National Health and Medical Research Council Centres of Research Excellence, has successfully contributed to shaping research activity regarding the purpose, focus, viability, intended outcomes and, potentially, the research methods adopted to undertake the respective research [21]. This implementation demonstrates the capacity for many similar frameworks, such as Payback, the Balanced Scorecard, the Translational Research Organizations Performance Model, the Comprehensive Research Metrics model, the ITHS KLM–WHO model, the RE-AIM model and REF to develop this capability, given their shared characteristics [28, 42, 44, 45, 54, 55].


Health and medical research conducted under the umbrella of MRIs has a substantial impact beyond traditional academic outputs. RIAFs provide a mechanism to both demonstrate and encourage such impacts. This paper examined the objectives presented for research impact assessment in light of economic imperatives to justify on-going government support for HMR investment, leverage productivity via commercialisation and outcome-efficiency gains in the health system, and embed translation and impact into the research process.

The research found that many frameworks do not have an explicit purpose, nor are they systematically designed to realise these imperatives or other objectives, despite the relevance of purpose to their form, method and content. A potential reason for this omission lies in the hegemony of the ‘4A’ objectives of accountability, advocacy, analysis and allocation, presented in formative work by the RAND Corporation [38, 56]. Whether these objectives are explicit or implicit, the majority of the evaluated frameworks possess the capability to provide information for accountability, advocacy and strategic management decisions, i.e. analysis and allocation, to varying degrees. Collectively, they provide sufficient information to address the initial imperative to justify investment and provide for gradual improvement. This research sought to question whether the objectives included in ‘4A’ are sufficient to address the other imperatives, and specifically whether the objectives can be expanded to pro-actively encourage research impact in line with the latter two imperatives.

To the extent that Management Learning and Feedback seeks to inform upon the allocation of funds, such as the United Kingdom REF [35] and MCRI’s Research Performance Evaluation Framework [32], or the refinement of subsequent research activity, then most frameworks are indirectly concerned with accelerating translation and improving the productive impact of HMR. The main challenge with retrospective reviews relates to the time lag in these decisions. Retrospective reviews of research projects, programs or grants, such as the United Kingdom REF process typically take 12 months [35], if not years, for the feedback to actively inform research decisions. For regular evaluations, it is possible that expectations of the review will prospectively shape practice and consequently accelerate translation. However, the speed of translation will only be optimised if decisions to improve research translation and impact are made prospectively; that is, during the research process. When reviewed against the criteria for prospective implementation or speed of translation, many of the frameworks were either insufficient to meet this requirement or, while capable of adaption, were not designed for this purpose. Even where a pro-active objective is noted, other priorities can dilute the effect. For example, the United Kingdom’s REF [28, 35] sought to encourage research impact, but the adopted method (peer-reviewed case studies) was ultimately informed by pragmatic considerations of assessment across multiple disciplines, rather than the need to drive productive outcomes.

The potential implications for the development of new or evolved RIAFs for MRIs are numerous. First, the primary objective/s for a framework should be made explicit. Second, the framework should be designed to realise these objectives. Third, the qualities of existing frameworks inform upon the guiding principles necessary to realise different objectives. If the objective is to encourage productive research outcomes through greater integration of translation and impact considerations into the research process, then prospective implementation and a focus upon the speed of translation merits prioritisation [57].

The limitations of this study include the scoping literature review methodology, which may not have captured all potentially relevant studies. Inclusion of the knowledge exchange/translation literature and hand-searching of references should have ensured that the majority of key documents were captured. The focus upon frameworks applied to HMR may also have excluded relevant research with implications for the generalisation of the conclusions beyond health research. The main limitation relates to the evaluation. While mitigated by the independent review process, the determination of the criteria and the evaluation of frameworks according to these criteria introduces subjectivity as to the capabilities of each RIAF. However, modest subjective differences in categorisation should not act to undermine the over-arching conclusion regarding the disconnection between the capabilities of most existing RIAFs and the economic imperatives driving their development and implementation. Inclusion of a third reviewer may have strengthened the research design, but was precluded by resource constraints.

These issues raise a number of additional questions. If the objective is to optimise research translation and impact, consistent with the economic imperatives to drive productive gains, then where should a framework be implemented? At one or more points through the research process or at the institutional level? Through academic track records or the research process? How would such a framework fit with the peer-review process? The value of a RIAF integrated with the research process would be that it acts less as an additional administrative burden upon researchers, and more as an enabling mechanism for researchers to demonstrate and optimise the translation and impact of their work. What would the attitude of researchers be to such an approach? Is it viable in practice? Questions of to whom, within what timeframe, of causality and attribution, also remain a challenge [5, 28, 40, 44]. How would a framework address these issues? If the primary challenge is to change research culture, is a resolution to these issues necessary or merited? What does this imply for the form and positioning of a framework? Are motivations and incentives correctly aligned to realise the intended objectives? How would a more comprehensive researcher-focussed framework fit with national engagement and impact assessment frameworks, such as the United Kingdom REF [28] or the framework under development by the Australian Research Council [30]? This research represents the first in a suite of research papers that seek to define a draft RIAF for Australia’s MRIs. These questions need to be addressed in subsequent research.


Significant expenditure has been incurred developing RIAFs, both in Australia and internationally. Greater resources will be consumed conducting research translation and impact assessments using such frameworks. Consequently, it is vital that these frameworks have the capacity to deliver upon their intended purpose.

This study demonstrates that, despite the centrality of purpose to evaluation, insufficient attention has been placed upon the question of ‘why?’. The main objective/s for a framework should be explicit and assessment frameworks should be explicitly designed to realise these objectives. The majority of RIAFs meet the objectives to provide accountability, and to varying degrees, advocacy and management learning and feedback. This capacity is adequate to address the first economic imperative to justify investment in HMR, but insufficient to optimise the actions, outcomes and impacts demanded by the second (leverage productivity) and third (quality improvement) economic imperatives. To address these imperatives, the capacity for a framework to be implemented prospectively and a focus upon the speed of translation merits prioritisation.


  1. At the time of writing, the Australian Research Council were undertaking a consultation process to develop an explicit Engagement and Impact Assessment framework that will provide more comprehensive information than contained with the existing Excellence in Research Australia, which is primarily a research quality framework.

  2. Measurement of Research Impact and Achievement was piloted, but not fully implemented, by the Australian National Health & Medical Research Council.


  1. Institute of Medicine. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research. Leshner AI, Terry SF, Schultz AM, Liverman CT, editors. Washington, DC: The National Academies Press; 2013;178p.

  2. Australian Government Department of Industry, Innovation and Science. Boosting the commercial returns from research. 2014. Accessed 1 June 2015.

  3. Warry P. Increasing the economic impact of research councils. London: Research Councils UK; 2006. Contract No.: 06/1678.

    Google Scholar 

  4. European Commission Directorate-General for Research. Assessing Europe’s University-Based Research. Expert group on assessment of university-based research. Brussels: European Commission; 2010.

    Google Scholar 

  5. Canadian Academy of Health Sciences. Making an Impact: A Preferred Framework and Indicators to Measure Returns on Investment in Health Research. Ottawa: CAHS; 2009.

    Google Scholar 

  6. Brutscher P-B, Wooding S, Grant J. Health Research Evaluation Frameworks: An International Comparison. Santa Monica: RAND; 2008.

    Google Scholar 

  7. Banzi R, Moja L, Pistotti V, Facchini A, Liberati A. Conceptual frameworks and empirical approaches used to assess the impact of health research: An overview of reviews. Health Res Policy Syst. 2011;9:26.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Milat AJ, Bauman AE, Redman S. A narrative review of research impact assessment models and methods. Health Res Policy Syst. 2015;13:18.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Chelimsky E. The Coming Transformations in Evaluation. Evaluation for the 21st Century: A Handbook. SAGE Publications, Inc. Thousand Oaks: SAGE Publications, Inc; 1997.

    Google Scholar 

  10. OECD. General Government Debt (Indicator). 2016. Accessed 4 February 2016.

  11. OECD. Restoring Public Finances, 2012 Update: Information by Country. 2012. Accessed 1 June 2015.

  12. OECD. OECD Science, Technology and Industry Scoreboard 2015. 2015. Accessed 1 Dec 2015.

  13. Australian Government Department of Health. Strategic Review of Health and Medical Research in Australia – Final Report (McKeon Review). Canberra: DoH; 2013.

    Google Scholar 

  14. Chalmers I, Bracken MB, Djulbegovic B, Garattini S, Grant J, Gülmezoglu AM, et al. How to increase value and reduce waste when research priorities are set. Lancet. 2014;383:156–65.

    Article  PubMed  Google Scholar 

  15. Chan A-W, Song F, Vickers A, Jefferson T, Dickersin K, Gøtzsche PC, et al. Increasing value and reducing waste: addressing inaccessible research. Lancet. 2014;383(9913):257–66.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Glasziou P, Altman DG, Bossuyt P, Boutron I, Clarke M, Julious S, et al. Reducing waste from incomplete or unusable reports of biomedical research. Lancet. 2014;383(9913):267–76.

    Article  PubMed  Google Scholar 

  17. Ioannidis JPA, Greenland S, Hlatky MA, Khoury MJ, Macleod MR, Moher D, et al. Increasing value and reducing waste in research design, conduct, and analysis. Lancet. 2014;383(9912):166–75.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Australian Government Department of Health. Review to Strengthen Independent Medical Research Institutes: Discussion Paper. Canberra: Department of Health; 2015.

    Google Scholar 

  19. Association of Australian Medical Research Institutes (AAMRI). Webpage: “About AAMRI members”. 2015. Accessed 1 July 2015.

  20. OECD. Frascati Manual 2015.  Accessed 7 June 2015.

  21. Searles A, Doran C, Attia J, Knight D, Wiggers J, Deeming S, Mattes J, Webb B, Hannan S, Ling R, Edmunds K, Reeves P, Nilsson M. An approach to defining and measuring research translation and research impact. Health Serv Res Policy. 2016;14:60.

    Article  Google Scholar 

  22. Rumrill PD, Fitzgerald SM, Merchant WR. Using scoping literature reviews as a means of understanding and interpreting existing literature. Work. 2010;35(3):399–404.

    PubMed  Google Scholar 

  23. Oxman AD, Schünemann HJ, Fretheim A. Improving the use of research evidence in guideline development: 14. Reporting guidelines. Health Res Policy Syst. 2006;4:26.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Royle P, Waugh N. Literature searching for clinical and cost-effectiveness studies used in health technology assessment reports carried out for the National Institute for Clinical Excellence appraisal system. Health Technol Assess (Winch Eng). 2003;7(34):1–51.

    Google Scholar 

  25. Rubio DM, Schoenbaum EE, Lee LS, Schteingart DE, Marantz PR, Anderson KE, et al. Defining translational research: Implications for training. Acad Med. 2010;85(3):470–5.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Trochim W, Kane C, Graham MJ, Pincus HA. Evaluating translational research: A process marker model. Clin Transl Sci. 2011;4(3):153–62.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Lavis J, Ross S, McLeod C, Gildiner A. Measuring the impact of health research. J Health Serv Res Policy. 2003;8(3):165–70.

    Article  PubMed  Google Scholar 

  28. Ovseiko PV, Oancea A, Buchan AM. Assessing research impact in academic clinical medicine: a study using Research Excellence Framework pilot impact indicators. BMC Health Serv Res. 2012;12:478.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Bernstein A, Hicks V, Borbey P, Campbell T, McAuley L, Graham ID. A Framework to Measure the Impact of Investments in Health Research (CIHR). Paris: Organisation for Economic Co-operation and Development; 2006.

    Google Scholar 

  30. Australian Research Council. Engagement and Impact Consultation Paper. 2016. Accessed 5 May 2016.

  31. Drummond MF, Sculpher MJ, Torrance GW, O’Brien BJ, Stoddart GL. Methods for the Economic Evaluation of Health Care Programmes. Thirdth ed. Oxford: Oxford University Press; 2005.

    Google Scholar 

  32. Schapper CC, Dwyer T, Tregear GW, Aitken M, Clay MA. Research performance evaluation: the experience of an independent medical research institute. Aust Health Rev. 2012;36(2):218–23.

    Article  PubMed  Google Scholar 

  33. Academy of Technological Sciences and Engineering. Research Engagement for Australia: Measuring Research Engagement between Universities and End Users. Melbourne: ATSE; 2015.

    Google Scholar 

  34. Glover M, Buxton M, Guthrie S, Hanney S, Pollitt A, Grant J. Estimating the returns to UK publicly funded cancer-related research in terms of the net value of improved health outcomes. BMC Med. 2014;12:99.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Khazragui H, Hudson J. Measuring the benefits of university research: Impact and the REF in the UK. Res Eval. 2015;24(1):51–62.

    Article  Google Scholar 

  36. Landry R, Amara N, Lamari M. Climbing the ladder of research utilization: evidence from social science research. Sci Commun. 2001;22(4):396.

    Article  Google Scholar 

  37. Khoury MJ, Gwinn M, Yoon PW, Dowling N, Moore CA, Bradley L. The continuum of translation research in genomic medicine: How can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med. 2007;9(10):665–74.

    Article  PubMed  Google Scholar 

  38. Guthrie S, Wamae W, Diepeveen S, Wooding S, Grant J. Measuring Research: A Guide to Research Evaluation Frameworks and Tools. Santa Monica: RAND Corporation; 2013. p. 186.

    Google Scholar 

  39. Research Excellence Framework. Assessment Framework and Guidance on Submissions (updated to include addendum published in January 2012). 2014. Accessed 1 May 2015.

  40. Kuruvilla S, Mays N, Pleasant A, Walt G. Describing the impact of health research: a Research Impact Framework. J Health Serv Res Policy. 2007;12:23–31.

    Article  Google Scholar 

  41. Deloitte AE. Extrapolated Returns from Investment in Medical Research Future Fund (MRFF). Canberra: ASMR; 2015.

    Google Scholar 

  42. Young J, Bell R, Khalfan A, Lindquist E. Evaluating the Balanced Scorecard at the University Health Network: an impact assessment. Healthc Q. 2008;11(2):52–6.

    Article  PubMed  Google Scholar 

  43. Schweikhart SA, Dembe AE. The applicability of Lean and Six Sigma techniques to clinical and translational research. J Invest Med. 2009;57(7):748–55.

    Article  Google Scholar 

  44. Pozen R, Kline H. Defining success for translational research organizations. Sci Transl Med. 2011;3(94):94cm20.

    Article  PubMed  Google Scholar 

  45. Buxton M, Hanney S. How can payback from health services research be assessed? J Health Serv Res Policy. 1996;1(1):35–43.

    CAS  PubMed  Google Scholar 

  46. Telethon Kids Institute. Telethon Kids Institute Research Impact Framework (Draft). 2015.

  47. Scott CS, Nagasawa PR, Abernethy NF, Ramsey BW, Martin PJ, Hacker BM, et al. Expanding Assessments of Translational Research Programs: Supplementing Metrics With Value Judgments. Eval Health Prof. 2014;37(1):83–97.

    Article  PubMed  PubMed Central  Google Scholar 

  48. National Health & Medical Research Council NHaMRC. Measurement of (health and medical) research impact and achievement (MORIA) - Briefing, progress review and planning meeting. [Presentation]. 31 August 2006.

  49. Weiss AP. Measuring the impact of medical research: moving from outputs to outcomes. Am J Psychiatry. 2007;164(2):206–14.

    Article  PubMed  Google Scholar 

  50. Australian Research Council, Commonwealth of Australia. The State of Australian University Research 2015–16: Volume 1 ERA National Report. 2015. Accessed 1 June 2016.

  51. Buykx P, Humphreys J, Wakerman J, Perkins D, Lyle D, Mcgrail M, et al. ‘Making evidence count’: A framework to monitor the impact of health services research. Aust J Rural Health. 2012;20(2):51–8.

    Article  PubMed  Google Scholar 

  52. Mostert SP, Ellenbroek SPH, Meijer I, van Ark G, Klasen EC. Societal output and use of research performed by health research groups. Health Res Policy Syst. 2010;8:30.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Wiegers SE, Houser SR, Pearson HE, Untalan A, Cheung JY, Fisher SG, et al. A metric-based system for evaluating the productivity of preclinical faculty at an academic medical center in the era of clinical and translational science. Clin Transl Sci. 2015;8(4):357–61.

    Article  PubMed  Google Scholar 

  54. Glasgow RE, Vogt TM, Boles SM. Evaluating the Public Health Impact of Health Promotion Interventions: The RE-AIM Framework. Am J Public Health. 1999;89(9):1322–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Engel-Cox JA, Van Houten B, Phelps J, Rose SW. Conceptual model of comprehensive research metrics for improved human health and environment. Environ Health Perspect. 2008;116(5):583–92.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Morgan Jones M, Grant J, RAND Europe. Making the grade: methodologies for assessing and evidencing research impact. In: Dean AWM, Stevens H, editors. Seven essays on impact DESCRIBE project report for JISC. Exeter: University of Exeter; 2013. p. 25–43.

    Google Scholar 

  57. Trochim WM, Rubio DM, Thomas VG. Evaluation guidelines for the Clinical and Translational Science Awards (CTSAs). Clin Transl Sci. 2013;6(4):303–9.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Van Ark GKE. Societal impact of health research. J Health Sci. 2007;85(5):259–61.

    Google Scholar 

  59. Jacob R, Mcgregor, M. Assessing the Impact of Health Technology Assessment. International Journal of Technology Assessment in Health Care. 1997;13(01):68–80.

    Article  CAS  PubMed  Google Scholar 

  60. Sarli CC, Dubinsky EK, Holmes KL. Beyond citation analysis: a model for assessment of research impact. Journal of the Medical Library Association : JMLA. 2010;98(1):17–23.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Dembe AE, Lynch MS, Gugiu PC, Jackson RD. The Translational Research Impact Scale: Development, Construct Validity, and Reliability Testing. Eval Health Prof. 2014;37(1):50–70.

    Article  PubMed  Google Scholar 

  62. Spoth R, Rohrbach LA, Greenberg M, Leaf P, Brown CH, Fagan A, et al. Addressing Core Challenges for the Next Generation of Type 2 Translation Research and Systems: The Translation Science to Population Impact (TSci Impact) Framework. Prev Sci. 2013;14(4):319–51.

    Article  PubMed  PubMed Central  Google Scholar 

Download references


The authors would like to acknowledge feedback on an early draft by Professor Kypros Kypri and on a late draft by Dr Shanthi Ramanathan.


The research presented in this paper was supported by a grant from the Australian Department of Industry, Innovation and Science (DIIS). The grant contains no suppression clauses and the Department had no influence over the study design, analysis, interpretation or presentation of the results. Intellectual property and responsibility for the content of the paper rests with the authors.

Availability of data and materials

Not applicable.

Authors’ contributions

SD led the research, including the research context, the research objectives, methods, results, discussion and conclusion. He conducted the initial review of the objectives identified in the literature, the initial evaluation of the capacity of the respective Research Impact Assessment Frameworks to realise the objectives and drafted the paper. AS was involved in the research aims and general positioning of the research. He conducted the independent review of the objectives identified in the literature, the independent evaluation of the capacity of the respective Research Impact Assessment Frameworks to realise the objectives and provided feedback into the drafts. PR provided feedback to the initial drafts. MN initiated the research, synchronised the research aims with medical and health research policy development, and provided feedback to the initial drafts. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Not applicable.

Ethics approval and consent to participate

Ethics approval has been provided for the study by the Human Research Ethics Committee of the University of Newcastle, NSW, Australia; Reference No: H-2015-0250.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Simon Deeming.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Deeming, S., Searles, A., Reeves, P. et al. Measuring research impact in Australia’s medical research institutes: a scoping literature review of the objectives for and an assessment of the capabilities of research impact assessment frameworks. Health Res Policy Sys 15, 22 (2017).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: